Article
Providing biological context for GWAS results using eQTL regulatory and co-expression networks in Populus.
The New phytologist - 1 Oct 2024
Shu Mengjun, Yates Timothy B, John Cai, Harman-Ware Anne E, Happs Renee M, Bryant Nathan, Jawdy Sara S, Ragauskas Arthur J, Tuskan Gerald A, Muchero Wellington, Chen Jin-Gui
Abstract excerpt
Our study utilized genome-wide association studies (GWAS) to link nucleotide variants to traits in Populus trichocarpa, a species with rapid linkage disequilibrium decay. The aim was to overcome the challenge of interpreting statistical associations at individual loci without sufficient biological context, which often leads to reliance solely on gene annotations from unrelated model organisms. We employed an...
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