Article
Deletions in the MAL gene result in loss of Mal protein, defining the rare inherited AnWj-negative blood group phenotype.
Blood - 26 Dec 2024
Tilley Louise A, Karamatic Crew Vanja, Mankelow Tosti J, AlSubhi Samah A, Jones Benjamin, Borowski Abigail, Yahalom Vered, Finkel Lilach, Singleton Belinda K, Walser Piers J, Toye Ashley M, Satchwell Timothy J, Thornton Nicole M
Abstract excerpt
ABSTRACT: The genetic background of the high prevalence red blood cell antigen AnWj has remained unresolved since its identification in 1972, despite reported associations with both CD44 and Smyd1 histone methyltransferase. Development of anti-AnWj, which may be clinically significant, is usually due to transient suppression of antigen expression, but a small number of individuals with persistent, autosomally...
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