Article
HLA class-I polymorphisms among the Punjabi population of Pakistan: A comparative analysis with country's other ethnic groups.
Human immunology - 1 Sept 2024
Mirza Aliza, Ali Qadri Mian Mubeen, Zeshan Basit, Hafiz Kashif, Abbas Saba, Ahmad Nabeel, Iqbal Maryam
Abstract excerpt
The Punjabi population, constituting over 45 % of the country's total population, holds the highest prevalence in Pakistan. To understand their HLA genetics, we genotyped 389 Punjabi subjects for major Class-I loci using the PCR-SSO Luminex® method. Our study identified a total of 162 alleles, including 41 different HLA-A, 72 HLA-B, and 49 HLA-C alleles. The most common alleles included A*11:01 (14.6 %), A*01:01...
Topics
- Female
- Humans
- Male
- Alleles
- Ethnicity
- Gene Frequency
- Genetics, Population
- Genotype
- Haplotypes
- Histocompatibility Antigens Class I
- Linkage Disequilibrium