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Transcriptome and microbiome-immune changes across preinvasive and invasive anal cancer lesions

18 Jul 2024

Abstract excerpt

Anal squamous cell carcinoma (ASCC) is a rare gastrointestinal malignancy linked to high-risk human papillomavirus (HPV) infection, which develops from precursor lesions like low-grade squamous intraepithelial lesions and high-grade squamous intraepithelial lesions (HGSILs). ASCC incidence varies across populations and poses increased risk for people living with HIV. Our investigation focused on transcriptomic...

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PMID: 39024554
DOI: 10.1172/jci.insight.180907

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