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Article

Toll-like receptor 4 mutation mitigates gut microbiota-mediated hypertensive kidney injury.

Pharmacological research - 1 Aug 2024

Majumder Suravi, Pushpakumar Sathnur B, Almarshood Hebah, Ouseph Rosemary, Gondim Dibson D, Jala Venkatakrishna R, Sen Utpal

Abstract excerpt

Hypertension-associated dysbiosis is linked to several clinical complications, including inflammation and possible kidney dysfunction. Inflammation and TLR4 activation during hypertension result from gut dysbiosis-related impairment of intestinal integrity. However, the contribution of TLR4 in kidney dysfunction during hypertension-induced gut dysbiosis is unclear. We designed this study to address this knowledge...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 39002869
DOI: 10.1016/j.phrs.2024.107303
PMCID: PMC11287947

Genes

TLR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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