Article
Exploring the evidence for mitochondrial dysfunction and genetic abnormalities in the etiopathogenesis of tropical ataxic neuropathy.
Journal of neurogenetics - 1 Jun 2024
Sharma Shivani, Mahadevan Anita, Narayanappa Gayathri, Debnath Monojit, Govindaraj Periyasamy, Shivaram Sumanth, Seshagiri Doniparthi V, Siram Ramesh, Shroti Akhilesh, Bindu Parayil S, Chickabasaviah Yasha T, Taly Arun B, Nagappa Madhu
Abstract excerpt
Tropical ataxic neuropathy (TAN) is characterised by ataxic polyneuropathy, degeneration of the posterior columns and pyramidal tracts, optic atrophy, and sensorineural hearing loss. It has been attributed to nutritional/toxic etiologies, but evidence for the same has been equivocal. TAN shares common clinical features with inherited neuropathies and mitochondrial disorders, it may be hypothesised that genetic...
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