Article
Molecular characterization and clinical relevance of metabolic signature subtypes in gastric cancer.
Cell reports - 23 Jul 2024
Chen Hao, Jing Changqing, Shang Liang, Zhu Xingyu, Zhang Ronghua, Liu Yuan, Wang Mingfei, Xu Kang, Ma Tianrong, Jing Haiyan, Wang Ze, Li Xin, Chong Wei, Li Leping
Abstract excerpt
Metabolic reprogramming dictates tumor molecular attributes and therapeutic potentials. However, the comprehensive metabolic characteristics in gastric cancer (GC) remain obscure. Here, metabolic signature-based clustering analysis identifies three subtypes with distinct molecular and clinical features: MSC1 showed better prognosis and upregulation of the tricarboxylic acid (TCA) cycle and lipid metabolism,...
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