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The distinct spatiotemporal evolutionary landscape of HBV and HDV largely determines the unique epidemic features of HDV globally.

Molecular phylogenetics and evolution - 1 Aug 2024

Ding Yibo, Guo Hongbo, Hong Xinfang, Li Qiudi, Miao Zhijiang, Pan Qiuwei, Zheng Kuiyang, Wang Wenshi

Abstract excerpt

Chronic infection of hepatitis B virus (HBV) and hepatitis D virus (HDV) causes the most severe form of viral hepatitis. Due to the dependence on HBV, HDV was deemed to co-evolve and co-migrate with HBV. However, we previously found that the naturally occurred HDV/HBV combinations do not always reflect the most efficient virological adaptation (Wang et al., 2021). Moreover, regions with heavy HBV burden do not...

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Identifiers

PMID: 38825156
DOI: 10.1016/j.ympev.2024.108114

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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