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Article

Stereotactic radiotherapy vs whole brain radiation therapy in EGFR mutated NSCLC: Results & reflections from the prematurely closed phase III HYBRID trial.

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology - 1 Aug 2024

Zeng Ming, Verma Vivek, Chen Xue, Li Simin, Sun Yongliang, Liu Guotao, Tian Xiaoman, Zhang Deng, Li Jingqiu, Liu Yi, Liao Xingyu, Liu Yingyi, Wang Ling, Wang Xiao, Shi Huibing, Li Bin, Xue Binyue, Luo Xing

Abstract excerpt

BACKGROUND: All known randomized trials of stereotactic radiotherapy (SRT) versus whole brain radiotherapy (WBRT) for brain metastases (BMs) comprise mixed histologies. The phase III HYBRID trial (NCT02882984) attempted to evaluate the non-inferiority of SRT vs. WBRT specifically for EGFR-mutated non-small cell lung cancer (EGFRm NSCLC) BMs. METHODS: Inclusion criteria were ≤ 5 BMs (any size) from treatment-naïve...

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PMID: 38801945
DOI: 10.1016/j.radonc.2024.110334

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EGFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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