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An evaluation of the cost-effectiveness of population genetic screening for familial hypercholesterolemia in US patients.

Atherosclerosis - 1 Jun 2024

Hendy Lauren E, Spees Lisa P, Tak Casey, Carpenter Delesha M, Thomas Kathleen C, Roberts Megan C

Abstract excerpt

BACKGROUND AND AIMS: Familial hypercholesterolemia is an underdiagnosed genetic metabolic condition limiting the clearance of low-density lipoprotein cholesterol and increasing lifetime risk of cardiovascular disease. Population genetic screening in unselected individuals could quickly identify cases of familial hypercholesterolemia and enable early prevention, but the economic impact of widespread screening on...

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PMID: 38677159
DOI: 10.1016/j.atherosclerosis.2024.117541

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