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Article

RpoS Acts as a Global Repressor of Virulence Gene Expression in Escherichia coli O104:H4 and Enteroaggregative E coli.

The Journal of infectious diseases - 16 Oct 2024

Berger Petya, Dumevi Rexford M, Berger Michael, Hastor Ines, Treffon Janina, Kouzel Ian U, Kehl Alexander, Scherff Natalie, Dobrindt Ulrich, Mellmann Alexander

Abstract excerpt

In 2011, in Germany, Escherichia coli O104:H4 caused the enterohemorrhagic E coli (EHEC) outbreak with the highest incidence rate of hemolytic uremic syndrome. This pathogen carries an exceptionally potent combination of EHEC- and enteroaggregative E coli (EAEC)-specific virulence factors. Here, we identified an E coli O104:H4 isolate that carried a single-nucleotide polymorphism (SNP) in the start codon (ATG >...

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PMID: 38526342
DOI: 10.1093/infdis/jiae151

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