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A distinct Fusobacterium nucleatum clade dominates the colorectal cancer niche

20 Mar 2024

Abstract excerpt

Abstract Fusobacterium nucleatum ( Fn ), a bacterium present in the human oral cavity and rarely found in the lower gastrointestinal tract of healthy individuals 1 , is enriched in human colorectal cancer (CRC) tumours 2–5 . High intratumoural Fn loads are associated with recurrence, metastases and poorer patient prognosis 5–8 . Here, to delineate Fn genetic factors facilitating tumour colonization, we generated...

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PMID: 38509359
DOI: 10.1038/s41586-024-07182-w

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