Article
In vitro activity of the anthelmintic drug niclosamide against Sporothrix spp. strains with distinct genetic and antifungal susceptibility backgrounds.
Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] - 1 Jun 2024
Ramos Mariana Lucy Mesquita, Almeida-Silva Fernando, de Souza Rabello Vanessa Brito, Nahal Juliana, Figueiredo-Carvalho Maria Helena Galdino, Bernardes-Engemann Andrea Reis, Poester Vanice Rodrigues, Xavier Melissa Orzechowski, Meyer Wieland, Zancopé-Oliveira Rosely Maria, Frases Susana, Almeida-Paes Rodrigo
Abstract excerpt
The drugs available to treat sporotrichosis, an important yet neglected fungal infection, are limited. Some Sporothrix spp. strains present reduced susceptibility to these antifungals. Furthermore, some patients may not be indicated to use these drugs, while others may not respond to the therapy. The anthelmintic drug niclosamide is fungicidal against the Sporothrix brasiliensis type strain. This study aimed to...
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