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Article

Optimal sequence of LT for symptomatic BM in EGFR-mutant NSCLC: a comparative study of first-line EGFR-TKIs with/without upfront LT.

Journal of cancer research and clinical oncology - 19 Feb 2024

Niu Lishui, Wu Honghua, Gao Ruihuan, Chen Liu, Wang Jiangtao, Duan Hexin, Long Yujiao, Xie Yi, Zhou Qin, Zhou Rongrong

Abstract excerpt

BACKGROUND: The third-generation epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) can penetrate blood-brain barrier and are effective for brain metastases (BMs). There is no consensus on the optimal sequence of local therapy (LT) and EGFR-TKIs for symptomatic BM patients because patients suffering neurological symptoms were not enrolled in most clinical trials. METHODS: Non-small cell lung...

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Identifiers

PMID: 38369644
DOI: 10.1007/s00432-023-05538-9
PMCID: PMC10874906

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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