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Article

Spatiotemporal genotype replacement of H5N8 avian influenza viruses contributed to H5N1 emergence in 2021/2022 panzootic.

Journal of virology - 19 Mar 2024

Zeng Jinfeng, Du Fanshu, Xiao Linna, Sun Honglei, Lu Lu, Lei Weipan, Zheng Jialu, Wang Lu, Shu Sicheng, Li Yudong, Zhang Qiang, Tang Kang, Sun Qianru, Zhang Chi, Long Haoyu, Qiu Zekai, Zhai Ke, Li Zhichao, Zhang Geli, Sun Yipeng, Wang Dayan, Zhang Zhengwang, Lycett Samantha J, Gao George F, Shu Yuelong, Liu Jinhua, Du Xiangjun, Pu Juan

Abstract excerpt

Since 2020, clade 2.3.4.4b highly pathogenic avian influenza H5N8 and H5N1 viruses have swept through continents, posing serious threats to the world. Through comprehensive analyses of epidemiological, genetic, and bird migration data, we found that the dominant genotype replacement of the H5N8 viruses in 2020 contributed to the H5N1 outbreak in the 2021/2022 wave. The 2020 outbreak of the H5N8 G1 genotype...

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PMID: 38358287
DOI: 10.1128/jvi.01401-23
PMCID: PMC10949427

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