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Gestational diabetes augments group B Streptococcus infection by disrupting maternal immunity and the vaginal microbiota

3 Feb 2024

Abstract excerpt

Group B Streptococcus (GBS) is a pervasive perinatal pathogen, yet factors driving GBS dissemination in utero are poorly defined. Gestational diabetes mellitus (GDM), a complication marked by dysregulated immunity and maternal microbial dysbiosis, increases risk for GBS perinatal disease. Using a murine GDM model of GBS colonization and perinatal transmission, we find that GDM mice display greater GBS in utero...

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PMID: 38310089
DOI: 10.1038/s41467-024-45336-6

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