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Urinary microbiome-based metagenomic signature for the noninvasive diagnosis of hepatocellular carcinoma

26 Jan 2024

Abstract excerpt

BACKGROUND: Gut microbial dysbiosis is implicated in chronic liver disease and hepatocellular carcinoma (HCC), but the role of microbiomes from various body sites remains unexplored. We assessed disease-specific alterations in the urinary microbiome in HCC patients, investigating their potential as diagnostic biomarkers. METHODS: We performed cross-sectional analyses of urine samples from 471 HCC patients and 397...

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PMID: 38278977
DOI: 10.1038/s41416-024-02582-1

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