Article
Genetic variants in the HLA region contribute to the risk of cerebral palsy.
Biochimica et biophysica acta. Molecular basis of disease - 1 Mar 2024
Cheng Ye, Xu Yiran, Li Hongwei, Qiao Yimeng, Wang Yangong, Su Yu, Zhang Jin, Wang Xiaoyang, Song Lili, Ding Jian, Wang Dan, Zhu Changlian, Xing Qinghe
Abstract excerpt
Cerebral palsy (CP) is the most common physical disability in childhood, and genetic factors play an important role in its pathogenesis. However, the genetic contributions remain incompletely elucidated. Here, we conducted a two-stage association study between 1090 CP cases and 1100 healthy controls after whole exome sequencing. The human leukocyte antigen (HLA) allelic predispositions were further analyzed in...
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