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Article

Global Streptococcus pyogenes strain diversity, disease associations, and implications for vaccine development: a systematic review.

The Lancet. Microbe - 1 Feb 2024

Smeesters Pierre R, de Crombrugghe Gabrielle, Tsoi Shu Ki, Leclercq Céline, Baker Ciara, Osowicki Joshua, Verhoeven Caroline, Botteaux Anne, Steer Andrew C

Abstract excerpt

The high strain diversity of Streptococcus pyogenes serves as a major obstacle to vaccine development against this leading global pathogen. We did a systematic review of studies in PubMed, MEDLINE, and Embase that reported the global distribution of S pyogenes emm-types and emm-clusters from Jan 1, 1990, to Feb 23, 2023. 212 datasets were included from 55 countries, encompassing 74 468 bacterial isolates...

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Identifiers

PMID: 38070538
DOI: 10.1016/S2666-5247(23)00318-X

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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