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ALOX5 deficiency contributes to bladder cancer progression by mediating ferroptosis escape

7 Dec 2023

Abstract excerpt

Ferroptosis is an iron-dependent form of regulated cell death driven by the lethal lipid peroxides. Previous studies have demonstrated that inducing ferroptosis holds great potential in cancer therapy, especially for patients with traditional therapy failure. However, cancer cells can acquire ferroptosis evasion during progression. To date, the therapeutic potential of inducing ferroptosis in bladder cancer (BCa)...

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PMID: 38062004
DOI: 10.1038/s41419-023-06333-7

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