Severe communication delays are independent of seizure burden and persist despite contemporary treatments in SCN1A+ Dravet syndrome: Insights from the ENVISION natural history study.

doi:10.1111/epi.17850

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Article

Severe communication delays are independent of seizure burden and persist despite contemporary treatments in SCN1A+ Dravet syndrome: Insights from the ENVISION natural history study.

Epilepsia - 1 Feb 2024

Perry M Scott, Scheffer Ingrid E, Sullivan Joseph, Brunklaus Andreas, Boronat Susana, Wheless James W, Laux Linda, Patel Anup D, Roberts Colin M, Dlugos Dennis, Holder Deborah, Knupp Kelly G, Lallas Matt, Phillips Steven, Segal Eric, Smeyers Patricia, Lal Dennis, Wirrell Elaine, Zuberi Sameer, Brünger Tobias, Wojnaroski Mary, Maru Benit, O'Donnell Penrose, Morton Magda, James Emma, Vila Maria Candida, Huang Norman, Gofshteyn Jacqueline S, Rico Salvador

Abstract excerpt

OBJECTIVE: Dravet syndrome (DS) is a developmental and epileptic encephalopathy characterized by high seizure burden, treatment-resistant epilepsy, and developmental stagnation. Family members rate communication deficits among the most impactful disease manifestations. We evaluated seizure burden and language/communication development in children with DS. METHODS: ENVISION was a prospective, observational study...

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Identifiers

PMID: 38049202
DOI: 10.1111/epi.17850

Genes

SCN1A

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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