Article
Single nucleotide polymorphisms in vitamin D binding protein and 25-hydroxylase genes affect vitamin D levels in adolescents of Arab ethnicity in Kuwait.
Frontiers in endocrinology - 1 Jan 2023
Rahman Abdur, Abu-Farha Mohamed, Channanath Arshad, Hammad Maha M, Anoop Emil, Chandy Betty, Melhem Motasem, Al-Mulla Fahd, Thanaraj Thangavel Alphonse, Abubaker Jehad
Abstract excerpt
Vitamin D deficiency (VDD) is widespread in the Arab world despite ample sunshine throughout the year. In our previous study, lifestyle and socio-demographic factors could explain only 45% of variability in vitamin D levels in Kuwaiti adolescents, suggesting that genetics might contribute to VDD in this region. Single nucleotide polymorphisms (SNP) in the 25-hydroxylase (CYP2R1) and the GC globulin (GC) genes...
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