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Article

Ivosidenib: A Review in Advanced Cholangiocarcinoma.

Targeted oncology - 1 Nov 2023

Frampton James E

Abstract excerpt

Ivosidenib (Tibsovo®), a first-in-class, oral small molecule, potent and selective inhibitor of mutant isocitrate dehydrogenase 1 (mIDH1), is approved in the EU and USA for the treatment of adults with pretreated, advanced, mIDH1 cholangiocarcinoma (CCA). It is presumed to exert its cytostatic effects in this setting by suppressing 2-hydroxyglutarate, an oncometabolite produced by mIDH1 that impairs cellular...

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Identifiers

PMID: 37855990
DOI: 10.1007/s11523-023-01002-3
PMCID: PMC11467016

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