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Article

Intrinsic Resistance to Osimertinib in EGFR Mutated NSCLC Cell Lines Induced by Alteration in Cell-Cycle Regulators.

Targeted oncology - 1 Nov 2023

Volta Francesco, La Monica Silvia, Leonetti Alessandro, Gnetti Letizia, Bonelli Mara, Cavazzoni Andrea, Fumarola Claudia, Galetti Maricla, Eltayeb Kamal, Minari Roberta, Petronini Pier Giorgio, Tiseo Marcello, Alfieri Roberta

Abstract excerpt

BACKGROUND: Cell-cycle regulators are mutated in approximately 40% of all cancer types and have already been linked to worse outcomes in non-small cell lung cancer adenocarcinomas treated with osimertinib. However, their exact role in osimertinib resistance has not been elucidated. OBJECTIVE: In this study, we aimed to evaluate how the CDK4/6-Rb axis may affect the sensitivity to osimertinib. METHODS: We...

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Identifiers

PMID: 37855989
DOI: 10.1007/s11523-023-01005-0
PMCID: PMC10663255

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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