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Article

Structural and functional implications of SLC13A3 and SLC9A6 mutations: an in silico approach to understanding intellectual disability.

BMC neurology - 4 Oct 2023

Hussain Syeda Iqra, Muhammad Nazif, Shah Salah Ud Din, Fardous Fardous, Khan Sher Alam, Khan Niamatullah, Rehman Adil U, Siddique Mehwish, Wasan Shoukat Ali, Niaz Rooh, Ullah Hafiz, Khan Niamat, Muhammad Noor, Mirza Muhammad Usman, Wasif Naveed, Khan Saadullah

Abstract excerpt

BACKGROUND: Intellectual disability (ID) is a condition that varies widely in both its clinical presentation and its genetic underpinnings. It significantly impacts patients' learning capacities and lowers their IQ below 70. The solute carrier (SLC) family is the most abundant class of transmembrane transporters and is responsible for the translocation of various substances across cell membranes, including...

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PMID: 37794328
DOI: 10.1186/s12883-023-03397-y
PMCID: PMC10548666

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