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Gut microbes exacerbate systemic inflammation and behavior disorders in neurologic disease CADASIL

8 Sept 2023

Abstract excerpt

Abstract Background Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a cerebral small vessel disease that carries mutations in NOTCH3. The clinical manifestations are influenced by genetic and environmental factors that may include gut microbiome. Results We investigated the fecal metagenome, fecal metabolome, serum metabolome, neurotransmitters, and...

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Share to Cerebrovascular and genetic disorders
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PMID: 37684694
DOI: 10.1186/s40168-023-01638-3

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