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Cervicovaginal Gardnerella sialidase-encoding gene in persistent human papillomavirus infection

31 Aug 2023

Abstract excerpt

Disturbed vaginal microbiota have a role in the persistence of high-oncogenic-risk human papillomavirus (hrHPV) and Gardnerella spp. is closely related with this condition. Such bacteria are the major source of cervicovaginal sialidases, important for microbiota alterations. The sialidase-encoding gene nanH3 is account for their sialidase activity. Thus, a subset of 212 women positive for hrHPV at the first visit...

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PMID: 37652960
DOI: 10.1038/s41598-023-41469-8

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