Article
MiRNA-mRNA integrative analysis reveals epigenetically regulated and prognostic miR-103a with a role in migration and invasion of carboplatin-resistant ovarian cancer cells that acquired mesenchymal-like phenotype.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie - 1 Oct 2023
Pernar Kovač Margareta, Tadić Vanja, Kralj Juran, Milković Periša Marija, Orešković Slavko, Babić Ivan, Banović Vladimir, Zhang Wei, Culig Zoran, Brozovic Anamaria
Abstract excerpt
BACKGROUND: DNA methylation, histone modifications, and miRNAs affect ovarian cancer (OC) progression and therapy response. PURPOSE: Identification of epigenetically downregulated miRNAs in drug-resistant OC cell lines with a possible role in drug resistance and/or drug-induced mesenchymal-like phenotype. METHODS: MiRNA profiling was performed on parental and carboplatin-resistant OC cells, MES-OV and MES-OV CBP....
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