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Taxonomic and functional profiling of fecal metagenomes for the early detection of colorectal cancer

3 Aug 2023

Abstract excerpt

Objectives: This study aimed to identify colorectal cancer (CRC)-associated phylogenetic and functional bacterial features by a large-scale metagenomic sequencing and develop a binomial classifier to accurately distinguish between CRC patients and healthy individuals. Methods: We conducted shotgun metagenomic analyses of fecal samples from a ZhongShanMed discovery cohort of 121 CRC and 52 controls and SouthernMed...

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PMID: 37601681
DOI: 10.3389/fonc.2023.1218056

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