Article
Predicting BRAFV600E mutations in papillary thyroid carcinoma using six machine learning algorithms based on ultrasound elastography.
Scientific reports - 3 Aug 2023
Agyekum Enock Adjei, Wang Yu-Guo, Xu Fei-Ju, Akortia Debora, Ren Yong-Zhen, Chambers Kevoyne Hakeem, Wang Xian, Taupa Jenny Olalia, Qian Xiao-Qin
Abstract excerpt
The most common BRAF mutation is thymine (T) to adenine (A) missense mutation in nucleotide 1796 (T1796A, V600E). The BRAFV600E gene encodes a protein-dependent kinase (PDK), which is a key component of the mitogen-activated protein kinase pathway and essential for controlling cell proliferation, differentiation, and death. The BRAFV600E mutation causes PDK to be activated improperly and continuously, resulting...
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