Article
Integrated analysis of the transcriptome and its interaction with the metabolome in metabolic associated fatty liver disease: Gut microbiome signatures, correlation networks, and effect of PNPLA3 genotype.
Proteomics - 1 Sept 2023
Mascardi María Florencia, Mazzini Flavia Noelia, Suárez Bárbara, Ruda Vera M, Marciano Sebastián, Casciato Paola, Narvaez Adrián, Haddad Leila, Anders Margarita, Orozco Federico, Tamaroff Ana Jesica, Cook Frank, Gounarides John, Gutt Susana, Gadano Adrián, García Celia Méndez, Marro Martin L, Penas Steinhardt Alberto, Trinks Julieta
Abstract excerpt
Interactions between communities of the gut microbiome and with the host could affect the onset and progression of metabolic associated fatty liver disease (MAFLD), and can be useful as new diagnostic and prognostic biomarkers. In this study, we performed a multi-omics approach to unravel gut microbiome signatures from 32 biopsy-proven patients (10 simple steatosis -SS- and 22 steatohepatitis -SH-) and 19 healthy...
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