Article
[Role of metabolic energy in the regulation of chlortetracycline transport in Escherichia coli].
Mikrobiologiia - 1 Jan 2000
Klypina N S, Plakunov V K
Abstract excerpt
The uptake of chlorotetracycline by the E. coli K-12 strain sensitive to this antibiotic and by its resistant mutant E. coli E-6-X is regulated by the antibiotic transport being coupled and uncoupled with the metabolic energy, this being determined by the concentration of chlorotetracycline in the medium. If the level of the antibiotic is lower than the subbacteriostatic concentration, its accumulation by both...
Topics
- Absorption
- Biological Transport
- Chlortetracycline
- Culture Media
- Dose-Response Relationship, Drug
- Drug Resistance, Microbial
- Energy Metabolism
- Escherichia coli
- Mutation