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Article

Circulating miRNAs and their functional genetic variants in pseudoexfoliative glaucoma: potential of miR-146a-5p as a diagnostic biomarker.

International ophthalmology - 1 Nov 2023

Can Demirdöğen Birsen, Öztürk Başer Tuğba, Köylü Mehmet Talay, Özge Gökhan, Gürbüz Köz Özlem, Mumcuoğlu Tarkan

Abstract excerpt

PURPOSE: The etiology and pathogenesis of pseudoexfoliation syndrome (PEX) and its advancement into pseudoexfoliative glaucoma (PEG) are not fully understood. In this study, we aimed to evaluate the possible role played by two circulating microRNAs (miR-146a-5p and miR-196a-5p) in plasma and their functional genetic variants MIR146A rs2910164 and MIR196A2 rs11614913 in susceptibility to PEG or PEX. METHODS:...

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PMID: 37420124
DOI: 10.1007/s10792-023-02797-w

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