Article
USP51/PD-L1/ITGB1-deployed juxtacrine interaction plays a cell-intrinsic role in promoting chemoresistant phenotypes in non-small cell lung cancer.
Cancer communications (London, England) - 1 Jul 2023
Li Jianjun, Xiao Xuechun, Ou Yang, Cao Lixia, Guo Min, Qi Chunchun, Wang Zhaoyang, Liu Yuxin, Shuai Qiuying, Wang Hang, Sun Peiqing, Shi Yi, Yang Guang, Yang Shuang
Abstract excerpt
BACKGROUND: Programmed death ligand 1 (PD-L1) has been demonstrated to facilitate tumor progression and therapeutic resistance in an immune-independent manner. Nevertheless, the function and underlying signaling network(s) of cancer cell-intrinsic PD-L1 action remain largely unknown. Herein, we sought to better understand how ubiquitin-specific peptidase 51 (USP51)/PD-L1/integrin beta-1 (ITGB1) signaling performs...
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