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Interventions to support decision making in people considering germline genetic testing for BRCA 1/2 pathogenic and likely pathogenic variants: A scoping review.

Journal of genetic counseling - 1 Apr 2024

Pozzar Rachel A, Seven Memnun

Abstract excerpt

Pathogenic and likely pathogenic variants in BRCA1 and BRCA2 (BRCA1/2) are medically actionable and may inform hereditary breast and ovarian cancer (HBOC) treatment and prevention. However, rates of germline genetic testing (GT) in people with and without cancer are suboptimal. Individuals' knowledge, attitudes, and beliefs may influence GT decisions. While genetic counseling (GC) provides decision support, the...

Topics

Humans
Genetic Testing
BRCA2 Protein
Female
BRCA1 Protein
Decision Making
Genetic Counseling
Germ-Line Mutation
Breast Neoplasms
Genetic Predisposition to Disease
Ovarian Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 37328917
DOI: 10.1002/jgc4.1738

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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