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Article

Determinants of neuropsychiatric flares in patients with systemic lupus erythematosus: results from five phase III trials of belimumab.

Rheumatology (Oxford, England) - 1 Mar 2024

Palazzo Leonardo, Lindblom Julius, Cetrez Nursen, Ala Henri, Parodis Ioannis

Abstract excerpt

OBJECTIVE: To identify determinants of neuropsychiatric (NP) flares in patients with SLE treated for active SLE yet no ongoing severe NPSLE with non-biologic standard therapy plus belimumab or placebo. METHODS: We analysed data from five phase III trials (BLISS-52, BLISS-76, BLISS-NEA, BLISS-SC, EMBRACE; n = 3638) after exclusion of patients with baseline NP BILAG A. Factors associated with NPSLE flare, defined...

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PMID: 37228034
DOI: 10.1093/rheumatology/kead249
PMCID: PMC10907808

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