Article
Identification of cough-variant asthma phenotypes based on clinical and pathophysiologic data.
The Journal of allergy and clinical immunology - 1 Sept 2023
Zhan Wenzhi, Wu Feng, Zhang Yunhui, Lin Lin, Li Wen, Luo Wei, Yi Fang, Dai Yuanrong, Li Suyun, Lin Jiangtao, Yuan Yadong, Qiu Chen, Jiang Yong, Zhao Limin, Chen Meihua, Qiu Zhongmin, Chen Ruchong, Xie Jiaxing, Guo Chunxing, Jiang Mei, Yang Xiaohong, Shi Guochao, Sun Dejun, Chen Rongchang, Zhong Nanshan, Shen Huahao, Lai Kefang
Abstract excerpt
BACKGROUND: Cough-variant asthma (CVA) may respond differently to antiasthmatic treatment. There are limited data on the heterogeneity of CVA. OBJECTIVE: We aimed to classify patients with CVA using cluster analysis based on clinicophysiologic parameters and to unveil the underlying molecular pathways of these phenotypes with transcriptomic data of sputum cells. METHODS: We applied k-mean clustering to 342 newly...
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