Article
3-Phosphoinositide-dependent kinase 1 drives acquired resistance to osimertinib.
Communications biology - 11 May 2023
Meraz Ismail M, Majidi Mourad, Fang Bingliang, Meng Feng, Gao Lihui, Shao RuPing, Song Renduo, Li Feng, Lissanu Yonathan, Chen Huiqin, Ha Min Jin, Wang Qi, Wang Jing, Shpall Elizabeth, Jung Sung Yun, Haderk Franziska, Gui Philippe, Riess Jonathan Wesley, Olivas Victor, Bivona Trever G, Roth Jack A
Abstract excerpt
Osimertinib sensitive and resistant NSCLC NCI-H1975 clones are used to model osimertinib acquired resistance in humanized and non-humanized mice and delineate potential resistance mechanisms. No new EGFR mutations or loss of the EGFR T790M mutation are found in resistant clones. Resistant tumors grown under continuous osimertinib pressure both in humanized and non-humanized mice show aggressive tumor regrowth...
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