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PcTrim prevents early infection with white spot syndrome virus by inhibiting AP1-induced endocytosis

8 May 2023

Abstract excerpt

Viruses have evolved various strategies to achieve early infection by initiating transcription of their own early genes via host transcription factors, such as NF-κb, STAT, and AP1. How the host copes with this immune escape has been a topic of interest. Tripartite motif (TRIM) family proteins with RING-type domains have E3 ubiquitin ligase activity and are known as host restriction factors. Trim has been...

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PMID: 37158899
DOI: 10.1186/s12964-023-01059-7

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