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Three-dimensional topological radiogenomics of epidermal growth factor receptor Del19 and L858R mutation subtypes on computed tomography images of lung cancer patients.

Computer methods and programs in biomedicine - 1 Jun 2023

Ninomiya Kenta, Arimura Hidetaka, Tanaka Kentaro, Chan Wai Yee, Kabata Yutaro, Mizuno Shinichi, Gowdh Nadia Fareeda Muhammad, Yaakup Nur Adura, Liam Chong-Kin, Chai Chee-Shee, Ng Kwan Hoong

Abstract excerpt

OBJECTIVES: To elucidate a novel radiogenomics approach using three-dimensional (3D) topologically invariant Betti numbers (BNs) for topological characterization of epidermal growth factor receptor (EGFR) Del19 and L858R mutation subtypes. METHODS: In total, 154 patients (wild-type EGFR, 72 patients; Del19 mutation, 45 patients; and L858R mutation, 37 patients) were retrospectively enrolled and randomly divided...

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PMID: 37148668
DOI: 10.1016/j.cmpb.2023.107544

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