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Improved Dried Blood Spot PCR Assay for Universal Congenital Cytomegalovirus Screening in Newborns

20 Mar 2023

Abstract excerpt

Implementation of screening for cCMV in public health programs is hindered by feasibility challenges, including limited specimen availability and an insufficiently sensitive DBS-based screening assay. We report on efforts to improve the currently available DBS-based molecular assay to increase its feasibility of implementation in newborn screening programs. Although the analytical sensitivity of the modified...

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PMID: 36939327
DOI: 10.1128/spectrum.04041-22

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