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Article

Fibroblast growth factor 5 (FGF5) and its missense mutant FGF5-H174 underlying trichomegaly: a molecular dynamics simulation investigation.

Journal of biomolecular structure & dynamics - 1 Jan 2023

Hoang Skyler H

Abstract excerpt

The missense mutation Y174H of FGF5 (FGF5-H174) had been associated with trichomegaly, characterized by abnormally long and pigmented eyelashes. The amino acid tyrosine (Tyr/Y) at position 174 is conserved across many species, proposedly holding important characteristics for the functions of FGF5. Microsecond molecular dynamics simulations along with protein-protein docking and residue interacting network...

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PMID: 36905676
DOI: 10.1080/07391102.2023.2188953

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