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Article

Telomere attrition and genomic instability in unexplained recurrent pregnancy loss in humans: A preliminary study.

Mutation research. Genetic toxicology and environmental mutagenesis - 1 Jan 2000

Chakraborty Abhik, Roy Souvick, Hande Manoor Prakash, Banerjee Birendranath

Abstract excerpt

Genome instability is defined as an elevated rate of DNA damage and mutations as a result of exposure to potential direct and indirect mutagens. This current investigation was designed to elucidate the genomic instability among couples experiencing unexplained recurrent pregnancy loss (uRPL). A cohort of 1272 individuals with history of unexplained RPL with normal karyotype was retrospectively screened for levels...

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PMID: 36868694
DOI: 10.1016/j.mrgentox.2022.503580

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