Article
Human bocavirus 1 and 2 genotype-specific antibodies for rapid antigen testing in pediatric patients with acute respiratory infections.
World journal of pediatrics : WJP - 1 Oct 2023
De Ri, Xu Yan-Peng, Wang Fang, Zhou Yu-Tong, Shi Pan-Deng, Zhu Ru-Nan, Sun Yu, Liu Li-Ying, Jia Li-Ping, Dong Hui-Jin, Zhao Hui, Qin Cheng-Feng, Zhao Lin-Qing
Abstract excerpt
BACKGROUND: Previous serological studies of human bocavirus (HBoV) 1 could not exclude cross-reactivity with the other three HBoVs, particularly HBoV2. METHODS: To search for genotype-specific antibodies against HBoV1 and HBoV2, the divergent regions (DRs) located on the major capsid protein VP3 were defined through viral amino acid alignment and structure prediction. DR-deduced peptides were used as antigens to...
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