Germline predisposition to haematological malignancies: Best practice consensus guidelines from the UK Cancer Genetics Group (UKCGG), CanGene-CanVar and the NHS England Haematological Oncology Working Group.

doi:10.1111/bjh.18675

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Article

Germline predisposition to haematological malignancies: Best practice consensus guidelines from the UK Cancer Genetics Group (UKCGG), CanGene-CanVar and the NHS England Haematological Oncology Working Group.

British journal of haematology - 1 Apr 2023

Speight Beverley, Hanson Helen, Turnbull Clare, Hardy Steven, Drummond James, Khorashad Jamshid, Wragg Christopher, Page Paula, Parkin Nicholas W, Rio-Machin Ana, Fitzgibbon Jude, Kulasekararaj Austin Gladston, Hamblin Angela, Talley Polly, McVeigh Terri P, Snape Katie

Abstract excerpt

The implementation of whole genome sequencing and large somatic gene panels in haematological malignancies is identifying an increasing number of individuals with either potential or confirmed germline predisposition to haematological malignancy. There are currently no national or international best practice guidelines with respect to management of carriers of such variants or of their at-risk relatives. To...

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PMID: 36744544
DOI: 10.1111/bjh.18675

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