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Article

Adrenal Dysfunction in Mitochondrial Diseases

6 Jan 2023

Abstract excerpt

Cortisol is central to several homeostatic mechanisms including the stress and immune response. Adrenal insufficiency and impaired cortisol production leads to severe, potentially fatal disorders. Several fundamental stages of steroidogenesis occur within the mitochondria. These dynamic organelles not only contribute ATP for steroidogenesis, but also detoxify harmful by-products generated during cortisol...

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PMID: 36674647
DOI: 10.3390/ijms24021126

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