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Article

FAM111B dysregulation promotes malignancy in fibrosarcoma and POIKTMP and a low-cost method for its mutation screening.

Cancer treatment and research communications - 1 Jan 2023

Rhoda Cenza, Sunda Falone, Kidzeru Elvis, Khumalo Nonhlanhla P, Arowolo Afolake

Abstract excerpt

INTRODUCTION: Mutations in the uncharacterised human FAM111B gene are associated with POIKTMP, a rare multi-organ fibrosing disease. Recent studies also reported the overexpression of FAM111B in specific cancers. Moreover, FAM111B mutation screening may prove expensive in under-resourced facilities. Therefore, this study investigated its cellular function and dysfunction and described an inexpensive mutation...

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PMID: 36610347
DOI: 10.1016/j.ctarc.2022.100679

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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