Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Association of CDKAL1 gene polymorphism (rs10946398) with gestational diabetes mellitus in Pakistani population.

Molecular biology reports - 1 Jan 2023

Asghar Aleesha, Firasat Sabika, Afshan Kiran, Naz Shagufta

Abstract excerpt

BACKGROUND: CDK5 regulatory subunit associated protein 1 like 1 (CDKAL1) encodes a tRNA modifying enzyme involved in the proper protein translation and regulation of insulin production encoded by the CDKL gene. Sequence variations in the CDKAL1 gene lead to the misreading of the Lys codon in proinsulin, resulting in decreased glucose-stimulated proinsulin production. Various polymorphic sequence variants of the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Diabetes, Gestational
Share to Diabetes Mellitus, Type 2

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Insulin

Share to Pakistan

Share to Polymorphism, Single Nucleotide

Share to Pregnancy

Share to Proinsulin

Share to tRNA Methyltransferases

Source

Identifiers

PMID: 36301463
DOI: 10.1007/s11033-022-08011-x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Association of CDKAL1 gene polymorphism (rs10946398) with gestational diabetes mellitus in Pakistani population.PMID 36301463Read ↗

CDKAL1 gene rs7756992 A/G and rs7754840 G/C polymorphisms are associated with gestational diabetes mellitus in a sample of Bangladeshi population: implication for future T2DM prophylaxisSemantic proximity Read ↗

Association of the CDKAL1 polymorphism rs10946398 with type 2 diabetes mellitus in adults: A meta-analysis.Semantic proximity Read ↗

Association of CDKAL1 gene polymorphisms variations with gestational diabetes mellitus risk in women: A case-control study and meta-analysisSemantic proximity Read ↗

Association of the CDKAL1 gene polymorphism with gestational diabetes mellitus in Chinese women.Semantic proximity Read ↗

Single Nucleotide Polymorphisms in CDKAL1 Gene Are Associated with Risk of Gestational Diabetes Mellitus in Chinese PopulationSemantic proximity Read ↗

CDK5 Regulatory Subunit-Associated Protein 1-Like 1 Gene Polymorphisms and Gestational Diabetes Mellitus Risk: A Trial Sequential Meta-Analysis of 13,306 Subjects.Semantic proximity Read ↗

Association of six single nucleotide polymorphisms with gestational diabetes mellitus in a Chinese population.Semantic proximity Read ↗

Novel single nucleotide polymorphisms in gestational diabetes mellitus.Semantic proximity Read ↗

Variants of CDKAL1 rs7754840 (G/C) and CDKN2A/2B rs10811661 (C/T) with gestational diabetes: insignificant association.Semantic proximity Read ↗

GCK, GCKR, FADS1, DGKB/TMEM195 and CDKAL1 Gene Polymorphisms in Women with Gestational Diabetes.Semantic proximity Read ↗

FTO, GCKR, CDKAL1 and CDKN2A/B gene polymorphisms and the risk of gestational diabetes mellitus: a meta-analysis.Semantic proximity Read ↗

Identification of Genetic Variants of Gestational Diabetes in South Indians.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.