Article
APC germline pathogenic variants and epithelial ovarian cancer: causal or coincidental findings?
Journal of medical genetics - 1 May 2023
Vibert Roseline, Le Gall Jessica, Buecher Bruno, Mouret-Fourme Emmanuelle, Bataillon Guillaume, Becette Véronique, Trabelsi-Grati Olfa, Moncoutier Virginie, Dehainault Catherine, Carriere Jennifer, Schwartz Mathias, Suybeng Voreak, Bieche Ivan, Colas Chrystelle, Vincent-Salomon Anne, Stoppa-Lyonnet Dominique, Golmard Lisa
Abstract excerpt
APC germline pathogenic variants result in predisposition to familial adenomatous polyposis and extraintestinal tumours such as desmoid fibromatosis, medulloblastomas and thyroid cancers. They have also been recently involved in ovarian microcystic stromal tumours. APC inactivation has been described at the tumour level in epithelial ovarian cancers (EOCs). Here, we report the identification of APC germline...
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