Osimertinib + Savolitinib to Overcome Acquired MET-Mediated Resistance in Epidermal Growth Factor Receptor-Mutated, MET-Amplified Non-Small Cell Lung Cancer: TATTON.

doi:10.1158/2159-8290.CD-22-0586

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Osimertinib + Savolitinib to Overcome Acquired MET-Mediated Resistance in Epidermal Growth Factor Receptor-Mutated, MET-Amplified Non-Small Cell Lung Cancer: TATTON.

Cancer discovery - 9 Jan 2023

Hartmaier Ryan J, Markovets Aleksandra A, Ahn Myung Ju, Sequist Lecia V, Han Ji-Youn, Cho Byoung Chul, Yu Helena A, Kim Sang-We, Yang James Chih-Hsin, Lee Jong-Seok, Su Wu-Chou, Kowalski Dariusz M, Orlov Sergey, Ren Song, Frewer Paul, Ou Xiaoling, Cross Darren A E, Kurian Nisha, Cantarini Mireille, Jänne Pasi A

Abstract excerpt

MET-inhibitor and EGFR tyrosine kinase inhibitor (EGFR-TKI) combination therapy could overcome acquired MET-mediated osimertinib resistance. We present the final phase Ib TATTON (NCT02143466) analysis (Part B, n = 138/Part D, n = 42) assessing oral savolitinib 600 mg/300 mg once daily (q.d.) + osimertinib 80 mg q.d. in patients with MET-amplified, EGFR-mutated (EGFRm) advanced non-small cell lung cancer (NSCLC)...

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PMID: 36264123
DOI: 10.1158/2159-8290.CD-22-0586
PMCID: PMC9827108

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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